Helicobacter pylori

Two-thirds of the world’s population have H. pylori infection

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What is Helicobacter pylori (H. pylori)?

Helicobacter pylori (H. pylori) is a gram-negative bacillus that infects the human stomach mucosa and produces diseases of the upper gastrointestinal tract such as:1

  • Chronic gastritis
  • Peptic ulcer disease
  • Gastric marginal zone/mucosa-associated lymphoid tissue (MALT) lymphoma
  • Gastric carcinoma

What is the risk of getting H. pylori infection?

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Individuals who are infected with H. pylori never suffer symptoms related to the infection. However, H. pylori is the major cause of peptic ulcer disease and gastritis.2 Infected persons have a 2 to 6 fold increased risk for developing gastric cancer and mucosal-associated lymphoid- type (MALT) lymphoma.3

Who should seek evaluation?

evaluation

All patients with active peptic ulcer disease (PUD), a past history of PUD (unless previous cure of H. pylori infection has been documented), low-grade (MALT) lymphoma, and a history of endoscopic resection of early gastric cancer (EGC) should be tested for H. pylori infection.4

GenPath offers a comprehensive menu of testing options to detect H. pylori infection:

IF YOU FEEL YOU NEED TO BE TESTED FOR H. PYLORI INFECTION, PLEASE SEE YOUR MEDICAL DOCTOR.

References

  1. I. Thung, H. Aramin, V. Vavinskaya et al., Review article: The Global Emergence of Helicobacter pylori antibiotic resistance, AP&T Alimentary Pharmacology and Therapeutics 2016; 43: 514-533
  2. Helicobacter pylori and Cancer, National Cancer Institute https://www.cancer.gov/about-cancer/causes-prevention/risk/infectious-agents/h-pylori-fact-sheet. Accessed 12.21.2017
  3. Helicobacter pylori and Peptic Ulcer Disease The Key to Cure, https://www.cdc.gov/ulcer/keytocure.htm#tested. Accessed 12.21.17
  4. W. Chey, G. Leontiadis, C. Howden et al., ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Am J Gastroenterol 2017; 112:212-238, published online 10 January 2017

H. pylori has been identified as the primary cause of gastric cancer

H. pylori infection remains one of the most chronic bacterial infection affecting humans