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Hereditary Prostate Cancer

Testing with the Hereditary Prostate Cancer Panel may be appropriate if your patient’s individual and/or family history is suggestive of a hereditary predisposition to prostate cancer. Recent updates to national guidelines can assist with identifying patients at risk for hereditary prostate cancer.

If there is a personal history of prostate cancer:

  • Clinically high-or very-high localized risk (T3 or higher, grade group 4 or higher, PSA ≥ 20 ng/mL)
  • Regional (Any T, N1, M0) or metastatic (Any T, Any N, M1), diagnosed at any age
  • Gleason score ≥7, particularly with family history of prostate or other related cancer(s)
  • Intraductal histology
  • Ashkenazi Jewish ancestry
  • Somatic tumor testing showing one of the following:
  • Abnormal MSI/IHC tumor testing indicating mismatch repair deficiency
  • Abnormal prostate tumor sequencing showing a variant in a gene associated with hereditary prostate cancer
  • Diagnosed <60 years of age, particularly with family history of prostate or other related cancer(s)
  • Diagnosed >60 years of age AND
  • A personal history of a second related cancer in the same individual OR
  • A father, brother, or ≥ 2 first, second, or third-degree relatives on the same side of the family with prostate cancer (diagnosed <60 years of age) or other related cancer(s)

If there is not a personal history of prostate cancer:

  • A first, second, or third-degree relative meeting one of the above criteria
  • A known pathogenic variant for hereditary cancer in a blood relative

The panel consists of 16 genes associated with an increased risk for prostate and other cancers.

Genes tested for in this panel include: ATM, BRCA1, BRCA2, BRIP1, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, RAD51C, RAD51D, and TP53.

Test CodeTest Name
J665-1Hereditary Prostate Cancer Panel