ONKOSIGHT ADVANCED™ NEXT GENERATION SEQUENCING

GenPath® proudly presents OnkoSight AdvancedTM, an exclusive product line offering both targeted and comprehensive next-generation sequencing assays designed for solid tumors and hematologic malignancies. Clinicians can opt for a focused panel, concentrating on actionable alterations in prevalent cancers, or a broader, more comprehensive panel. Our commitment is not only to deliver high-quality testing but also to address common challenges such as Turnaround Time (TAT) and Quantity Not Sufficient (QNS) rates. Backed by our in-house experts, OnkoSight Advanced empowers clinicians with precision and efficiency in cancer diagnostics.

OnkoSight Advanced Highlights:

  • Option for targeted or comprehensive panels
  • Industry-leading TATs and QNS rates
  • Tumor Mutation Burden (TMB) and Tumor-only Microsatellite Instability (MSI) included (on solid tumors, lymphoid, and multiple myeloma)
  • Whole genome Copy Number Variant (CNV) calling on select panels

Solid Tumor

Test Code TJ16-5

AKT1
APC
ARID1A
ATM
BRAF
BRCA1
BRCA2
CDH1
CDKN2A
CTNNB1
EGFR
EPCAM
ERBB2
ERBB4
FBXW7
FGFR1
FGFR2
FGFR3
GNA11
GNAQ
GNAS
HRAS
IDH1
IDH2
KDR
KIT
KRAS
MEN1
MET
MLH1
MSH2
MSH6
NOTCH1
NRAS
PDGFRA
PIK3CA
PMS2
POLE
PTEN
PTPN11
RB1
RET
SMAD4
SMO
STK11
TERT
TSC1
TSC2
TP53
VHL

Test Code: TP51-9

ARID1A
ATM
BRAF
BRCA2
CCND1
CCNE1
CDKN2A
CREBBP
EGFR
EP300
ERBB2
ERBB3
ERCC2
FANCA
FBXW7
FGFR1
FGFR2
FGFR3
HRAS
KDM6A
KMT2A
KMT2C
KMT2D
KRAS
LRP1B
MAP2K1
MDM2
NF1
NRAS
PIK3CA
PRKDC
PTEN
RB1
SMARCA4
SPEN
STAG2
TERT
TP53
TSC1

Test Code: TP57-6

AKT1
AR
ATM
ATR
ATRX
BARD1
BRAF
BRCA1
BRCA2
BRIP1
CCNE1
CDH1
CDK12
CHEK1
CHEK2
EGFR
EPCAM
ERBB2
ERBB3
ERBB4
ESR1
FANCA
FANCC
FANCL
FGFR1
FGFR2
FOXA1
KRAS
MLH1
MRE11A
MSH2
MSH6
MUTYH
MYC
NBN
PALB2
PIK3CA
PMS2
PTEN
RAD50
RAD51
RAD51B
RAD51C
RAD51D
RAD54L
RB1
RECQL4
TERT
TP53
XRCC2

Test Code: TH50-8

AKT1
APC
ATR
BRAF
CHEK1
EGFR
EPCAM
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR3
FGFR4
HRAS
KRAS
MET
MAP2K1
MLH1
MSH2
MSH6
NRAS
NTRK1
PIK3CA
PMS2
POLD1
POLE
PTEN
SMAD4
STK11
TERT
TP53

Test Code: TH57-3

APC
ATR
ATRX
BRAF
CDKN2A
CHEK1
CTNNB1
EGFR
ERBB2
H3F3A
H3F3B
H3F3C
HIST1H3B
HIST1H3C
IDH1
IDH2
MET
MYC
MYCN
NF1
NF2
NTRK1
PDGFRA
PIK3CA
PTEN
SMARCA4
SMARCB1
TERT
TP53
VHL

Test Code: TH58-1

BRAF
ERBB3
KIT
NF1
NTRK1
PDGFRA
SDHA
SDHB
SDHC
SDHD

Test Code: TH53-2

AKT1
AR
ATM
BRAF
BRCA1
BRCA2
BRIP1
CDH1
CDK12
CHEK1
CHEK2
EGFR
EPCAM
ERBB2
ERBB3
ESR1
FANCA
FANCC
FANCL
FGFR1
FGFR2
FOXA1
KRAS
MLH1
MRE11A
MSH2
MSH6
MUTYH
NBN
MYC
NF1
NTRK1
PALB2
PIK3CA
PMS2
POLE
PTEN
RAD50
RAD51B
RAD51C
RAD51D
RAD54L
RB1
RECQL4
SLX4
SMARCA4
TBX3
TERT
TP53
XRCC2

Test Code: TH59-9

BAP1
BRAF
BRCA2
CDK4
CDKN2A
CTNNB1
EIF1AX
GNA11
GNAQ
GNAS
KIT
MAP2K1
MITF
NBN
NF1
NRAS
NTRK1
PALB2
PDGFRA
PIK3CA
PTEN
RB1
SF3B1
SMO
SRC
TERT
TP53

Test Code: TH49-0

AKT1
ALK
ATR
BRAF
CHEK1
DDR2
EGFR
ERBB2
ERBB3
FGFR1
HRAS
KRAS
MAP2K1
MET
NRAS
NTRK1
PIK3CA
POLD1
POLE
ROS1
STK11
TERT
TP53

Test Code: TK84-0

ARID1A
BRAF
BRCA1
BRCA2
CCNE1
ERBB2
FGFR1
FGFR2
FGFR3
IDH1
IDH2
KRAS
MLH1
MSH2
MSH6
NRAS
PALB2
PIK3C2G
PMS2
STK11
TGFBR2
TP53
VHL

Test Code: TH48-2

AKT1
 AR
 ARID1A
 ATM
 ATR
 BARD1
 BRCA1
 BRCA2
 BRAF
 BRIP1
 CCND1
 CCNE1
 CDK12
 CHD1
 CHEK1
 CHEK2
 CTNNB1
 EPCAM
 FAM175A
 FANCA
 FANCD2
 FANCL
 FOXA1
 FOXO1
 GEN1
 HOXB13
 HRAS
 IDH1
 MLH1
 MRE11A
 MSH2
 MSH6
 MUTYH
 MYC
 NBN
 NTRK1
 PALB2
 PIK3CA
 PMS2
 PPP2R2A
 PTEN
 RAD51B
 RAD51C
 RAD51D
 RAD54L
 RB1
 SPOP
 TERT
 TP53

Chronic Lymphoid Neoplasm

Test Code: TH55-7 (for BM and PB specimen); TJ93-4 (for FFPE specimen)

ATM
BCL2
BCL6
BIRC3
BRAF
BTK
CARD11
CD79B
CDKN2A
CREBBP
CXCR4
DNMT3A
EP300
EZH2
IDH1
IDH2
IKZF1
IRF4
JAK1
JAK3
KMT2D
KRAS
MAP2K1
MEF2B
MYC
MYD88
NOTCH1
NOTCH2
NRAS
PIK3CA
PIK3CG
PLCG2
PTPRD
RHOA
SETD2
SF3B1
STAT3
STAT5B
TET2
TNFRSF14
TP53

Multiple Myeloma

Test Code: TL67-3 (for BM and PB specimen); TL68-1 (for FFPE specimen)

AKT1
AKT2
AKT3
ATM
ATR
B2M
BIRC3
BRAF
CCND1
CDK4
CDKN1B
CDKN2A
CXCR4
CYLD
DIS3
DNMT3A
EGFR
FAM46C
FGFR3
FUBP1
IDH1
IDH2
IGF1R
IKZF1
IRF4
JAK2
KDM6A
KRAS
MAX
MYC
MYD88
NF1
NFKBIA
NOTCH1
NRAS
PIK3CA
PIK3CG
PIK3R1
PIK3R2
PIM1
PRDM1
PSMB8
PTPN11
RB1
STAT3
TERT
TET2
TGFBR2
TP53
TRAF2

Myeloid Malignancies

Test Code: M374-7

75-gene DNA (Test code TM00-2)

73-gene Fusions (Test code TP02-2)

Test Code: TM00-2

ABL1
ANKRD26
ASXL1
ATRX
BCOR
BCORL1
BRAF
BTK
CALR
CBL
CBLB
CBLC
CCND2
CDC25C
CDKN2A
CEBPA
CSF3R
CUX1
CXCR4
DCK
DDX41
DHX15
DNMT3A
ETNK1
ETV6
EZH2
FBXW7
FLT3
GATA1
GATA2
GNAS
HRAS
IDH1
IDH2
IKZF1
JAK2
JAK3
KDM6A
KIT
KMT2A
KRAS
LUC7L2
MAP2K1
MPL
MYC
MYDD88
NF1
NOTCH1
NPM1
NRAS
PDGFRA
PHF6
PPM1D
PTEN
PTPN11
RAD21
RBBP6
RPS14
RUNX1
SETBP1
SF3B1
SH2B3
SLC29A1
SMC1A
SMC3
SRSF2
STAG2
STAT3
TWT2
TP53
U2AF1
U2AF2
WT1
XPO1
ZRSR2

Test Code: TL95-4

ABL1
ANKRD26
ASXL1
ATRX
BCOR
BCORL1
BRAF
CALR
CBL
CCND2
CDKN2A
CEBPA
CSF3R
CUX1
DDX41
DNMT3A
ETNK1
ETV6
EZH2
FBXW7
FLT3
GATA2
HRAS
IDH1
IDH2
JAK2
KDM6A
KIT
KMT2A
KRAS
MAP2K1
MPL
MYD88
NF1
NPM1
NRAS
PDGFRA
PHF6
PTEN
PTPN11
RUNX1
SETBP1
SF3B1
SRSF2
STAG2
TET2
TP53
U2AF1
WT1
ZRSR2

Test Code: TL94-7

ASXL1
BRAF
BCOR
CEBPA
CSFR3
DDX41
DNMT3A
ETV6
EZH2
FLT3
GATA2
HRAS
IDH1
IDH2
JAK2
KIT
KMT2A
KRAS
NF1
NPM1
NRAS
PDGFRA
PHF6
PTPN11
RUNX1
SETBP1
STAG2
TET2
TP53
WT1

Test Code: TL96-2

ABL1
ASXL1
CALR
CBL
CSF3R
DNMT3A
EZH2
IDH1
IDH2
JAK2
KIT
MPL
SETBP1
SF3B1
SRSF2
TP53
U2AF1

Test Code: TL97-4

JAK2 (exon 12 and V617F)
CALR
MPL

Test Code: TL98-8

ASXL1
BCOR
CBL
DNMT3A
ETV6
EZH2
JAK2
KRAS
NRAS
PTPN11
RUNX1
SETBP1
SF3B1
SRSF2
TET2
TP53
U2AF1
ZRSR2

*Virtual karyotyping or CNA assessment will require samples with >50% tumor content. Normal findings will not be reported. For TJ16, CNA assessment will be performed on samples with an indication for tumor subtypes with HRD-associated therapy including high-grade serous ovarian (HGSO), fallopian tube and mesenteric, prostate, breast, and pancreaticobiliary.

GenPath is one of the select National Cancer Institute- Molecular Analysis for Therapy Choice (NCI-MATCH) clinical trials network laboratories, with DLAP approved solid tumor assays.

Healthcare providers should only order panels if each gene or test in the panel is medically necessary.