Hereditary Cancer Testing

GenPath offers a comprehensive menu of testing options for hereditary cancer syndromes, going beyond BRCA to ensure that our test options meet each individual patient’s needs.

Through our sister company, GeneDx, over 45,000 cases have been tested for pathogenic (harmful) variants in genes that increase an individual’s risk for acquiring cancer. GeneDx is a pioneer in the inherited disorders industry:

  • GeneDx was the first to commercially launch next-generation sequencing (NGS) in 2008 and,
  • GeneDx employs thought-leaders who are co-authors of established guidelines, such as the ACMG guidelines on NGS.

 

GeneDx Development Timeline:
GeneDx Timeline 7.18.16

 

TEST OPTIONS FOR HEREDITARY CANCER PANELS


Breast/Gyn Cancer
BRCA1/BRCA2 Ashkenazi Founder Panel
BRCA1 c.68_69delAG, c.5266dupC, BRCA2 c.5946delT
Breast/Gyn Cancer Panel
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM*, FANCC, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, PALB2, PMS2, POLD1, PTEN, RAD51C, RAD51D, RECQL, TP53
Breast Cancer Management Panel
ATM, BRCA1, BRCA2, CDH1, CHEK2, NBN, PALB2, PTEN, TP53
Colorectal Cancer
Lynch / Colorectal
High Risk Panel
APC, EPCAM*, MLH1, MSH2, MSH6, MUTYH, PMS2
Colorectal Cancer Panel
APC, ATM, AXIN2, BMPR1A, CDH1, CHEK2, EPCAM*, MLH1, MSH2, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, PTEN, SCG5/GREM1*, SMAD4, STK11, TP53
 
 
Urologic Cancer
Hereditary Prostate Panel
ATM, BRCA1, BRCA2, BRIP1, CHEK2, EPCAM*, HOXB13, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, RAD51C, RAD51D, TP53 .
Renal Cancer Panel
BAP1, EPCAM*, FH, FLCN, MET, MITF*, MLH1, MSH2, MSH6, PMS2, PTEN, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, VHL
 
 
Other Cancer
Comprehensive Common Cancer Panel
APC, ATM, AXIN2, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM*, FANCC, FH, FLCN, HOXB13, MET, MITF*, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTEN, RAD51C, RAD51D, RECQL, SCG5/GREM1*, SDHB, SDHC, SDHD, SMAD4, STK11, TP53, TSC1, TSC2, VHL
Common Cancer Management Panel
APC, ATM, AXIN2, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDKN2A, CHEK2, EPCAM*, FH, FLCN, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SCG5/GREM1*, SDHB, SDHC, SDHD, SMAD4, STK11, TP53, TSC1, TSC2, VHL
Melanoma Panel
BAP1, BRCA2, CDK4, CDKN2A, MITF*, POT1, PTEN, RB1,TP53
Pancreatic Cancer Panel
APC, ATM, BRCA1, BRCA2, CDK4, CDKN2A, EPCAM*, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, TP53, VHL
*Testing includes sequencing and deletion duplication for all genes except EPCAM (del/dup only),
MITF (evaluation of c.952G>A only), and SCG5/GREM1 (del/dup only).

FORMS TO DOWNLOAD
Family Hx Questionnaire Medicare Criteria Form Hereditary Cancer TRF Prefilled ABN Form
Fam Hx Q thumbnail Medicare Thumbnail IC req thumbnail ABN thumbnail