OnkoSight AdvancedTM for Myeloid Malignancies

Myeloid malignancies are clonal disorders of the progenitor cells or hematopoietic stem cells, which are comprised of acute stages (e.g., acute myeloid leukemia) and chronic phases including myeloproliferative neoplasms, myelodysplastic disorders, and chronic myelomonocytic leukemia.

Assessment of actionable mutations by next-generation sequencing (NGS) is a powerful tool to define diagnosis, determine prognostic risk, monitor measurable residual disease, and uncover predictive mutational markers and therapeutic targets, and is now a routine component in the workup and monitoring of hematological disorders.

GenPath®, a division of BioReference HealthTM, LLC, offers a vast menu of NGS panels for myeloid malignancies. Panel inclusive of DNA and RNA genes is also available.

Test Information

Test Code: M374-7

75-gene DNA (Test code TM00-2)

73-gene Fusions (Test code TP02-2)

TM00-2

ABL1
 ANKRD26
 ASXL1
 ATRX
 BCOR
 BCORL1
 BRAF
 BTK
 CALR
 CBL
 CBLB
 CBLC
 CCND2
 CDC25C
 CDKN2A
 CEBPA
 CSF3R
 CUX1
 CXCR4
 DCK
 DDX41
 DHX15
 DNMT3A
 ETNK1
 ETV6
 EZH2
 FBXW7
 FLT3
 GATA1
 GATA2
 GNAS
 HRAS
 IDH1
 IDH2
 IKZF1
 JAK2
 JAK3
 KDM6A
 KIT
 KMT2A
 KRAS
 LUC7L2
 MAP2K1
 MPL
 MYC
 MYD88
 NF1
 NOTCH1
 NPM1
 NRAS
 PDGFRA
 PHF6
 PPM1D
 PTEN
 PTPN11
 RAD21
 RBBP6
 RPS14
 RUNX1
 SETBP1
 SF3B1
 SH2B3
 SLC29A1
 SMC1A
 SMC3
 SRSF2
 STAG2
 STAT3
 TET2
 TP53
 U2AF1
 U2AF2
 WT1
 XP01
 ZRSR2

TL95-4

ABL1
 ANKRD26
 ASXL1
 ATRX
 BCOR
 BCORL1
 BRAF
 CALR
 CBL
 CCND2
 CDKN2A
 CEBPA
 CSF3R
 CUX1
 DDX41
 DNMT3A
 ETNK1
 ETV6
 EZH2
 FBXW7
 FLT3
 GATA2
 HRAS
 IDH1
 IDH2
 JAK2
 KDM6A
 KIT
 KMT2A
 KRAS
 MAP2K1
 MPL
 MYD88
 NF1
 NPM1
 NRAS
 PDGFRA
 PHF6
 PTEN
 PTPN11
 RUNX1
 SETBP1
 SF3B1
 SRSF2
 STAG2
 TET2
 TP53
 U2AF1
 WT1
 ZRSR2

TL94-7

ASXL1
 BRAF
 BCOR
 CEBPA
 CSFR3
 DDX41
DNMT3A
 ETV6
 EZH2
 FLT3
 GATA2
 HRAS
 IDH1
 IDH2
 JAK2
 KIT
 KMT2A
 KRAS
 NF1
 NPM1
 NRAS
 PDGFRA
 PHF6
 PTPN11
 RUNX1
 SETBP1
 STAG2
 TET2
 TP53
 WT1

TL98-8

ASXL1
 BCOR
 CBL
 DNMT3A
 ETV6
 EZH2
 JAK2
 KRAS
 NRAS
 PTPN11
 RUNX1
 SETBP1
 SF3B1
 SRSF2
 TET2
 TP53
 U2AF1
 ZRSR2

TL96-2

ABL1
 ASXL1
 CALR
 CBL
 CSF3R
 DNMT3A
 EZH2
 IDH1
 IDH2
 JAK2
 KIT
 MPL
 SETBP1
 SF3B1
 SRSF2
 TP53
 U2AF1

TL97-0

JAK2
CALR
MPL

++ Analyzed and reported in serial fashion until a mutation is found (JAK2 V617F if negative reflex to CALR, if negative reflex to MPL, if negative reflex to JAK2 exon 12).

TM07-7

CALR
JAK2
MPL

GenPath also offers singe-gene testing. Healthcare providers should only panels if each gene or test in the panel is medically necessary.