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Hematopathology
The Hematopathology Laboratory provides comprehensive diagnostic, prognostic and therapeutic information on a broad range of benign and malignant hematology and breast cancer disorders of peripheral blood, bone marrow and solid tissue utilizing state-of-the-art methodologies.
Coordinated analysis of specimens using these advanced techniques ensures that GenPath can provide physicians with a single source for diagnostic information and consultative services while providing accurate diagnostic testing, useful prognostic information and time-sensitive data for monitoring patient response to therapy.
Medical and Scientific Staff
GenPath's medical and scientific staff is comprised of an expert team of board-certified pathologists and laboratory scientists who carefully evaluate each case and are available for consultations and case reviews. We provide a personalized service with your patient foremost in mind. GenPath's impressive medical staff includes 21 board certified Anatomic and/or Clinical Pathologists, 9 board certified Hematopathologists, 4 board certified cytopathologists, 4 board certified dermatopathologists, 2 board certified internal medicine physicians and 2 board certified in clinical cytogenetics.
Testing services
GenPath has developed a comprehensive set of test profiles and algorithms for our clients in order to optimize diagnostic and therapeutic testing and disease monitoring. These are published in the GenPath “Hematopathology Disease-State Reference Guide”. GenPath’s state-of-the-art offerings include the latest molecular sequencing technologies such as pyrosequencing, multiplexed and quantitative real-tme PCR and microarray analysis. Recent offerings utilizing these new techniques include JAK2 mutation analysis, BCR/ABL mutation analysis, UGT1A1 polymorphism analysis, Hemochromatosis mutation analysis and TCRγ and B-cell clonality analyses.
Technologies
Flow cytometry
Flow cytometry has become a standard and routine practice for the evaluation of lymphomas and leukemia in most diagnostic laboratories. It is considered second to morphology for a diagnosis of hemato-lymphoid neoplasms. DNA ploidy and S-phase analysis by flow cytometry may be used as a tool in determining prognosis for patients with locally recurrent breast cancer.
Immunohistochemistry
Immunohistochemistry is a staining method that uses antibodies to identify and mark antigens expressed by cells in tissues. When histopathology alone proves inconclusive, Immunohistochemistry (IHC) can help determine diagnosis. Since mostantigens are not absolutely tumor-specific, panels of antibodies are employed to more fully characterize tissues.
Morphology
Bone marrow examination is critical for the care of patients with a wide variety of hematopoietic diseases.The presence of immature or morphologically atypical cells in the peripheral blood, an unexplained deficiency or excess of peripheral blood leukocytes or platelets, splenomegaly and unexplained anemia are common indications to obtain bone marrow specimens for diagnosis.
FISH
FISH is the application of fluorescently labeled DNA molecules to metaphase chromosomes and interphase nuclei for the detection of chromosome abnormalities and alterations. It is a rapid, reliable and direct approach for diagnosis, prognosis and management of hematologic malignancies.
Cytogenetics
Chromosome analysis for hematological disorders of bone marrow is performed to identify specific chromosome rearrangements. These rearrangements in neoplastic cells are often correlated to specific types of leukemia or myelodysplasias. This information aids the clinician in diagnosis, predicting prognosis, and guiding treatment.
Molecular Genetics
Molecular genetics testing can provide sensitive detection of neoplastic changes associated with malignancies such as APL, CML, FL and lymphoid neoplasms.
GenPath offers the following diagnostic testing services:
For more information about GenPath, please call us at 800-627-1479 or visit our Contact Us page.