| Test Name |
Dihydropyrimidine Dehydrogenase (DPD) Gene Mutation Analysis |
| Also Known As |
DPD-5 FU |
| Panel? |
No |
| Clinical Utility and/or Limitations |
"Partial or complete deficiency of DPD activity has been
associated with an increased risk for severe adverse
reactions when treated with pyrimidine-based
chemotherapeutic agents, such as 5-fluorouracil (5-FU).
The test can also be used to confirm the clinical
diagnosis of dihydropyrimidine dehydrogenase (DPD)
deficiency in affected patients and for the detection of
the IVS14+1G>A mutation in asymptomatic carriers."
|
| Diagnosis Under Consideration |
Dihydropyrimidine Dehydrogenase (DPD) , and for detection of the IVS14+1G>A mutation in asymptomatic carriers |
| Method |
Polymerase Chain Reaction, Oligonucleotide Hybridizations, and Chemiluminescent Detection |
| |
| Ordering Details |
| Test Code |
6285-1 |
| Assay Schedule |
Setup 1 day a week, A.M |
| Turnaround Time |
10- 15 days |
| Preferred Specimen and Volume |
5 mL EDTA Whole blood |
| Alternate Specimen and Volume |
5 mL ACD Whole blood |
| |
| Specimen Handling Information |
| Specimen Storage |
Room Temperature: 8 days, Refrigerated:8 days |
| Specimen Transport |
Ambient or refrigerated |
| |
| Billing Information |
| CPT Codes |
83891*1, 83896*2, 83898*1, 83908*1, 83912*1 |
| |
