| Test Name |
CYP2D6 |
| Also Known As |
Cytochrome P450 (CYP) 2D6 Pharmacogenomic Analysis |
| Panel? |
No |
| Clinical Utility and/or Limitations |
CYP2D6 is the major CYP isoform involved in tamoxifen metabolism to the antiestrogen endoxifen. CYP2D6 genetic variation and inhibitors of
the enzyme can markedly reduce endoxifen plasma concentrations in tamoxifen-treated patients. In fact, CYP2D6 has been shown to be an
independent predictive factor in women with breast cancer treated with tamoxifen. Tamoxifen-treated patients who are poor or intermediate
metabolizers (associated with impaired anti-estrogen metabolite production) had an increased incidence of recurrence and shorter relapsefree
periods. |
| Diagnosis Under Consideration |
Call lab |
| Method |
PCR |
| |
| Ordering Details |
| Test Code |
5287-8 |
| Turnaround Time |
3-4 days |
| Preferred Specimen and Volume |
5 mL Peripheral blood in EDTA tube |
| |
| Specimen Handling Information |
| Specimen Storage |
Refrigerate fresh specimen until shipping, ship within 24 hrs. |
| Specimen Transport |
Ship specimen with ice pack. |
| |
| Billing Information |
| CPT Codes |
83891x1, 83900x1, 83914x14, 83812x1 |
| |
| Other Information |
