| Test Name |
Chronic Lymphocytic Leukemia (CLL) Panel |
| Also Known As |
CLL Panel (+12, p53, D13s319, ATM) |
| Panel? |
Yes |
| Clinical Utility and/or Limitations |
Trisomy 12 (+12) is found in about 20% of CLL/SLL cases and is usually associated with an unfavorable response to chemotherapy and a predominantly unmutated IgVH gene status. D13s319- Deletions involving 13q14 are detectable by FISH in approximately 50% of persons with CLL. This deletion is associated with a favorable clinical outcome. ATM (11q22) Mutations of the ataxia-telangiectasia gene are seen in 10-20% of B-cell CLL and are associated with a relatively aggressive disease course and poorer prognosis. p53 (17p13) monosomy is usually associated with an unfavorable response to chemotherapy. |
| Diagnosis Under Consideration |
CLL Prognosis |
| Method |
FISH |
| |
| Ordering Details |
| Test Code |
5280-3 |
| Assay Schedule |
Mon - Sat, daily |
| Turnaround Time |
24-72hr Turnaround |
| Preferred Specimen and Volume |
2 mL Heparinized or EDTA Marrow, 5 mL Heparinized or EDTA Blood or Fresh Tissue in RPMI. |
| Alternate Specimen and Volume |
Non- decalcified Paraffin Embedded Tissue ( block) |
| |
| Specimen Handling Information |
| Specimen Storage |
Refrigerate fresh specimen until shipping, ship within 24 hrs. |
| Specimen Transport |
Ship specimen with ice pack. |
| Causes For Specimen Rejection |
No patient ID on Specimen, Patient ID on specimen and Requisition doesn't match, incorrect fixative (tube/solution), Specimen without GenPath/BioReference requisition. Frozen specimen. |
| |
| Billing Information |
| CPT Codes |
88368 (4) |
| |
